Curative effect of atorvastatin and rosuvastatin on carotid intima-media thickness of patients after PCI
10.3760/cma.j.issn.1008-6706.2016.06.023
- VernacularTitle:阿托伐他汀与瑞舒伐他汀对经皮冠状动脉介入治疗术后患者颈动脉内中膜厚度的影响
- Author:
Huimin GE
- Publication Type:Journal Article
- Keywords:
Atorvastatin;
Rosuvastatin;
Carotid intima -media thickness;
Percutaneous coronary intervention
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(6):884-886
- CountryChina
- Language:Chinese
-
Abstract:
Objective To discuss the influence of atorvastatin and rosuvastatin on carotid intima-media thickness(CIMT) of patients after percutaneous coronary intervention (PCI).Methods 142 patients after PCI with CIMT increasing were randomly divided into Lipitor group (n=71) and Crest group (n=71).The Lipitor group was given atorvastatin(20mg) orally once a day.The Crest group was given rosuvastatin(20mg) orally once a day.The changes of low density lipoprotein,high density lipoprotein,liver function and CIMT before and after 12 weeks treat-ment were observed in two groups.Results After treatment for 6 months, the levels of LDL-C, CIMT in Lipitor group were lower than before treatment with statistical difference[(3.37 ±1.20)mmol/L vs (2.0 ±0.29)mmol/L, (1.29 ±0.06)mm vs (0.91 ±0.23)mm](t=4.032,3.523,all P<0.05);the levels of LDL-C,CIMT in Crest group were lower than before treatment with statistical difference[(3.38 ±1.21)mmol/L vs (1.8 ±0.15)mmol/L, (1.30 ±0.16)mm vs (0.81 ±0.15)mm](t=4.700,3.892,all P<0.05).The decreasing degree of LDL-C, CIMT was significantly lower in Crest group than that in Lipitor group with statistical difference( t=3.668,3.002,all P<0.05 ) .The level of HDL -C in Lipitor group was higher than before treatment with statistical difference [(1.01 ±0.36)mmol/L vs (1.10 ±0.31)mmol/L](t=3.801,P<0.05).The level of HDL-C in Crest group was higher than before treatment with statistical difference[(1.03 ±0.32)mmol/L vs (1.15 ±0.35)mmol/L](t =3.722,P<0.05).The decrease degree of HDL-C was significantly higher in Crest group than that in Lipitor group with statistical difference(t=3.568,P<0.05).Conclusion Rosuvastatin has better effect than atorvastatin on the reversal of atherosclerosis process.
