Correlation between antimicrobial resistance of Acinetobacter baumannii and utilization of antimicrobial agents in our hospital
10.3760/cma.j.issn.1008-6706.2016.06.027
- VernacularTitle:某院鲍曼不动杆菌耐药率与抗菌药物使用量的相关性分析
- Author:
Nan ZHANG
;
Xinying WU
;
Junwen WANG
;
Huijuan YANG
;
Wenbin XIA
- Publication Type:Journal Article
- Keywords:
Acinetobacter baumannii;
Antibiotics;
Drug resistance rate;
Defined daily dose;
Corre-lation analysis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(6):897-900
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the correlation between the resistance of Acinetobacter baumannii and the utilization of antimicrobial agents in the hospitalized patients of Beijng Chuiyangliu Hospital,and provide the basis for clinical rational use antimicrobial agents.Methods A retrospective analysis was conducted for the drug resistance rate and specimen source of the 2 194 strains of Acinetobacter baumannii from 2010 to 2014 in the hospital and DDDs/DUI of antimicrobial agents was analyzed by Pearson correlation.Results The resistance rate of Acinetobacter baumannii was positively correlated with the DDDs and DUI of imipenem/cilastatin(r=0.991,0.994,all P<0.01), and was positively correlated with the DDDs of cefepime(r=0.934,P=0.020).The resistance rate of Acinetobacter baumannii to amikacin was positively correlated with the DDDs of etimicin(r=0.931,P=0.022).The resistance rate of Acinetobacter baumannii was negatively correlated with the DUI of levofloxacin(r =-0.986,P =0.002). Conclusion The resistance rate of Acinetobacter baumannii was high and there was correlation between the drug resistance and the utilization of some antimicrobial agents.
