Usefulness of Screening Ultrasonography for Hepatocellular Carcinoma Detection: Chronic Hepatitis Versus Hepatic Cirrhosis Caused by Hepatitis B Virus.
10.3348/jkrs.2004.51.3.307
- Author:
Samuel CHANG
1
;
Dongil CHOI
;
Jae Hoon LIM
;
Yunok PARK
;
Hyo Keun LIM
;
Won Jae LEE
;
Seung Hoon KIM
;
Kyung Mi JANG
;
Moon Seok CHOI
;
Seung Woon PAIK
Author Information
1. Department of Radiology and Center for Imaging Science, Korea. dichoi@smc.samsung.co.kr
- Publication Type:Original Article
- Keywords:
Cancer Screening;
Liver;
Ultrasound (US)
- MeSH:
Carcinoma, Hepatocellular*;
Early Detection of Cancer;
Hepatitis B virus*;
Hepatitis B*;
Hepatitis*;
Hepatitis, Chronic*;
Humans;
Liver;
Liver Cirrhosis*;
Liver Diseases;
Mass Screening*;
Retrospective Studies;
Ultrasonography*
- From:Journal of the Korean Radiological Society
2004;51(3):307-312
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: To evaluate the usefulness of screening liver ultrasonography (US) for hepatocellular carcinoma (HCC) detection in patients with chronic hepatitis or hepatic cirrhosis caused by hepatitis B virus (HBV). MATERIALS AND METHODS: A retrospective study was performed with 1,189 patients with clinical hepatopathy caused by HBV who underwent screening liver US for HCC detection at least twice. All patients were followed up with liver US examinations (mean, 8.3 times), CT, or MR for at least 3 months (range, 3-102 months; mean, 47 months) for the detection of HCC. The study population was divided into two groups: chronic hepatitis (n=492) and hepatic cirrhosis (n=697), which was further divided into two groups with (n=156) or without (n=541) evident shrinkage. The radiologic examinations that had detected HCC for the first time were analyzed and compared between the groups. RESULTS: Among 20 (4.1%) patients with chronic hepatitis and 132 (18.9%) patients with hepatic cirrhosis diagnosed as HCC, screening US was the modality of detection in 17 (85.0%) of 20 patients with chronic hepatitis and 76 (57.6%) of 132 patients with hepatic cirrhosis (p=0.038, Chi-square test). The detection rate of HCC on screening US between the chronic hepatitis and hepatic cirrhosis with evident shrinkage (51.4%, 19/37) showed a significant difference (p=0.027, Chi-square test). CONCLUSION: For chronic liver disease caused by HBV, screening US for HCC detection is more useful in patients with chronic hepatitis than with hepatic cirrhosis with evident shrinkage.
