Research progress of galactose - deficient IgA1 antibodies in diagnosis and treatment of IgA nephropathy
10.3760/cma.j.issn.2095-428X.2016.05.019
- VernacularTitle:异常糖基化IgA1抗体在IgA肾病诊治中的作用研究进展
- Author:
Hong ZHANG
;
Nan ZHOU
;
Ying SHEN
- Publication Type:Journal Article
- Keywords:
Galactose - deficient IgA1;
Galactose - deficient IgA1 antibodies;
IgA nephropathy
- From:
Chinese Journal of Applied Clinical Pediatrics
2016;31(5):392-394
- CountryChina
- Language:Chinese
-
Abstract:
In recent years,studies have shown that galactose - deficient IgA1(Gd - IgA1)antibodies are im-portant in the pathogenesis of IgA nephropathy(IgAN). Serum levels of Gd - IgA1 antibodies are associated with levels of proteinuria and renal histological grading. Measuring the antibodies has guidance value in the diagnosis of IgAN,for its sensitivity and specificity can be up to 88% - 89% and 89% - 92% respectively. In addition,the antibodies play an important role in clinical prognosis,and it may provide a new direction for treatment in IgAN. Now,its role in prognosis of IgAN was reviewed.
