Role of chronic inflammation in obesity-related glomerulopathy
10.3760/cma.j.issn.2095-428X.2016.05.020
- VernacularTitle:慢性炎症在肥胖相关性肾小球病中的作用
- Author:
Yanping GUO
;
Hongkun JIANG
- Publication Type:Journal Article
- Keywords:
Chronic inflammation;
Obesity;
Glomerulopathy;
Molecular mechanism
- From:
Chinese Journal of Applied Clinical Pediatrics
2016;31(5):395-397
- CountryChina
- Language:Chinese
-
Abstract:
In recently years,the incidence rate of obesity - related glomerulopathy(ORG)is increasing. Adi-pose tissue as a new endocrine organ releases inflammatory factors which can lead to glomerular artery endothelial damage,mesangial expansion and extracellular matrix accumulation and podocyte lesion,etc. Studies have confirmed that the chronic inflammation may play a key role in the pathogenesis of ORG. Now,the molecular mechanisms of chro-nic inflammation and its effect in the development of ORG were summarized.
