The effect of Xuebijing injection on coagulation function and prevention of deep venous thrombosis in elderly fracture patients with mechanical ventilation
10.3760/cma.j.issn.1008-6706.2016.05.009
- VernacularTitle:血必净注射液对老年骨折并机械通气患者凝血功能及深静脉血栓形成的影响
- Author:
Yunhai ZHANG
;
Jie XU
;
Menghua DENG
;
Haobo JIANG
;
Mingyuan MA
- Publication Type:Journal Article
- Keywords:
Xuebijing injection;
Fracture;
Mechanical ventilation;
Coagulation function;
DVT
- From:
Chinese Journal of Primary Medicine and Pharmacy
2016;23(5):675-678
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study effect of Xuebijing injection on coagulation function and prevention of deep venous thrombosis in elderly fracture patients with mechanical ventilation.Methods 60 patients were randomly divided into control group(30 cases) and Xuebijing group(30 cases).Xuebijing group received Xuebijing injection, besides physical therapy for prevention of deep venous thrombosis received by control group.Coagulation parameters and Lac at different time points,thrombosis incidence,hemorrhage incidence APACHE II score and 28 -day mortality were compared between the two groups.Results In Xuebijing group,PT,APTT,DD on d3 and Fg 48 on d5 had statistically significant differences compared with before treatment.PT,APTT on d3,d5 and DD on d5 were statistical-ly different compared with the control group(P <0.05).PLT,Lac,hemorrhage incidence and 28 -day mortality had no significant differences between the two groups.Thrombosis incidence in Xuebijing group was significantly lower than the control group(20.00% vs 3.33%) (χ2 =4.043,P =0.044,P <0.05).Both of APACHE II score were lower than before treatment,but the Xuebijing group was significantly decreased(t =5.48,P =0.000,P <0.05). Conclusion Xuebijing injection could improve coagulation function,and decrease thrombosis incidence in elderly fracture patients with mechanical ventilation.
