The structure and function of glycoprotein hormone receptor Lgr6

VernacularTitle:糖蛋白激素受体 Lgr6的结构和功能
Author: Man ZHANG ; Hui GAO
Publication Type:Journal Article
Keywords: Lgr6; Hair follicle stem cell; Tumour; R -spondin
From: Chinese Journal of Primary Medicine and Pharmacy 2016;23(5):780-782
CountryChina
Language:Chinese
Abstract: Objective Leucine -rich repeat (LRR) -containing G protein -coupled receptor 6 (Lgr6) is glycoprotein hormone receptor and a part of G protein -coupled receptors (GPCRs).Lgr6 is composed of 977 amino acid residues of a polypeptide chain.Having 17 leucine -rich repeats and seven transmembrane domain.In the N -and C -termini are connected with cysteine -rich sequences.It is highest homologous to Lgr4 and Lgr5,but less relationship with thyroid stimulating hormone receptor,progesterone receptor,and follicle -stimulating hormone recep-tor.Research found out that Lgr6 marks in the hair follicles of stem cells can differentiate into all cells in the skin and Lgr6 expression in tumor also has important biological significance.