Effects of long-term glucocorticoid administration on neuromuscular block of cisatracurium in elderly pa-tients undergoing general anesthesia
- VernacularTitle:长期糖皮质激素用药对老年患者全麻手术中顺阿曲库铵肌松效应的影响
- Author:
Xiaobing ZHU
;
Lun WU
;
Genbao WANG
;
Zhichao QI
;
Ying XIA
;
Xueqiang PENG
- Publication Type:Journal Article
- Keywords:
Glucocorticoid;
Neuromuscular block;
Elderly patients
- From:
The Journal of Clinical Anesthesiology
2016;32(3):262-264
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of long-term glucocorticoid administration on neuromuscular block of cisatracurium in elderly patients undergoing general anesthesia. Methods Forty ASA Ⅱ or Ⅲ patients,aged≥65 yr,with BMI of 18-24 kg/m2 ,scheduled for elec-tive operation were studied.According to the history of using or not long-term glucocorticoid,patients were assigned into two groups (n = 20 each):control group(group C),glucocorticoid group(group J).Midazolam 0.03 mg/kg was injected,mask inhalation of 8% sevoflurane and flow rate of oxygen 8L,every 30 s decline 2%,until the 4%.After the disappearance of eyelash reflex,cisatracurium 0.1 5 mg/kg was injected intravenously.After 1 min intravenous injection of remifentanil 2 g/kg and 30 s after stop of sevoflurane inhalation anesthesia, endotracheal intubation for mechanical ventilation,target controlled infusion of propofol and remifentanil anesthesia,using TOF-Watch SX acceleromyography monitoring of muscle relaxation,and onset time,clinical duration and recovery in-dex(for T1 to return from 25% to 75% of the control twitch)were recorded.Results Compared with group C,the onset time was significantly prolonged,clinical duration and recovery index were short-ened in group J (P <0.05 ).Conclusion Long-term glucocorticoid admininstration could reduce the neuromuscular blocking effect of cisatracurium in elderly patients.
