Oxycodone hydrochloride in postoperative analgesia in breast cancer patients undergoing modified radical mastectomy
- VernacularTitle:盐酸羟考酮在乳腺癌改良根治手术后急性疼痛治疗中的应用
- Author:
Zijing HE
;
Jing CHEN
;
Mi LI
;
Jinchong DUAN
;
Zhiyi FAN
- Publication Type:Journal Article
- Keywords:
Oxycodone;
Analgesia;
Postoperative pain;
PONV
- From:
The Journal of Clinical Anesthesiology
2016;32(3):255-257
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the safety and effective dose of oxycodone hydrochloride in-jection for postoperative analgesia in breast cancer patients undergoing modified radical mastectomy under general anesthesia in a prospective,randomized controlled clinical trial.Methods One hundred fe-male patients at ASAⅠ or Ⅱ,aged 29-69 years,BMI< 30 kg/m2 ,scheduled for elective modified radical mastectomy under general anesthesia,were randomly divided into two groups (n =50):low dose oxycodone hydrochloride injection group (group OL),and high dose oxycodone hydrochloride injection group (group OH).Oxycodone 0.03 mg/kg (group OL)and 0.09 mg/kg (group OH)was intravenous injected 30 mi-nutes before the end of the operation,respectively.Anesthetics usage was terminated when skin was sutured.Pain at rest and during movement was assessed using VAS score at 5 min,0.5,2,4,8,12 and 24 h after extubation of laryngeal mask.Total consumption of analgesic for rescue analgesia in the ward and the adverse events were recorded.Results Compared with group OL,group OH had lower VAS scores,There were significant differences in the VAS scores between groups at 8 and 12 h after surgery (P <0.05).No serious adverse event occurred in each group postoperatively.The most common adverse event was nausea, followed by vomiting and dizziness.There was no significant difference in the incidence of adverse event be-tween the two groups.Conclusion 0.09 mg/kg oxycodone hydrochloride injection is safe and effective in re-ducing pain after breast cancer radical operation.
