Pathological complete response of locally advanced gastric cancer after neoadjuvant chemotherapy:a report of five cases and a literature review
10.3969/j.issn.1000-8179.2016.06.436
- VernacularTitle:进展期胃癌新辅助化疗原发灶病理完全缓解5例报告及文献复习
- Author:
Liucheng WU
;
Mingwei HUANG
;
Yuzhou QIN
;
Jiansi CHEN
;
Xianwei MO
;
Haiming RU
- Publication Type:Journal Article
- Keywords:
gastric cancer;
neoadjuvant chemotherapy;
prognosis
- From:
Chinese Journal of Clinical Oncology
2016;43(6):265-270
- CountryChina
- Language:Chinese
-
Abstract:
Advanced gastric cancer without distant metastasis remains a potentially curable disease, but the prognosis is poor in this condition because of the high unresectability rate at presentation and the high recurrence rate after radical surgery. Administration of neoadjuvant chemotherapy has several potential benefits for advanced gastric cancer. This treatment can decrease tumor stage and improve R0 resection rate. Neoadjuvant chemotherapy has higher patient tolerability and a higher rate of chemotherapy completion than adjuvant chemotherapy. In vivo drug sensitivity tests can also be conducted to avoid unnecessary surgeries. Although high-intensi-ty chemotherapy results in a high overall response rate, a few advanced gastric patients can achieve a pathologically complete re-sponse. However, no standardized treatment has been achieved. This article introduces five cases of advanced gastric cancer treated with neoadjuvant chemotherapy in the Affiliated Tumor Hospital of Guangxi Medical University. The five cases achieved a pathological complete response. This article also aims to explore the clinicopathological characteristics of these patients, proper cooperative treat-ment practices, and prognostic factors for the benefit of future patients.
