Meta Analysis on Use Rate of Antibiotics in Outpatient Prescriptions of Primary Hospitals before and after the Implementation of Essential Drug Policy
- VernacularTitle:基本药物制度实施前后基层医院门诊处方抗菌药使用率的Meta分析
- Author:
Chen WANG
;
Jia YIN
;
Jinwen ZHANG
;
Shiwei GONG
- Publication Type:Journal Article
- Keywords:
Essential drug policy;
Primary hospitals;
Prescription use rate of antibiotics;
Meta analysis
- From:
China Pharmacist
2016;19(4):721-725
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To systematically evaluate the influence of the implementation of essential drug policy ( EDP) on prescrip-tion use rate of antibiotics in primary hospitals. Methods:Based on CNKI, Wanfang and VIP of China journal databases, all litera-tures were adopted including the data of the prescription use rate of antibiotics in primary hospitals. RevMan5. 3 and Stata 12. 0 soft-ware were used to conduct the Meta analysis. Results:Totally 43 literatures were included in the study according to the evaluation se-lection criteria. After the implementation of EDP, the prescription use rate of antibiotics in primary hospitals was decreased, and com-pared with that before the implementation of EDP, the risk difference value was significant [RD= -0. 03,95%CI( -0. 04,-0. 03), P<0. 000 01], while the use rate was still high (46. 16%). The result of Egger’s test indicated the publication bias of the 43 litera-tures was not significant (P=0. 571). However, there was high heterogeneity(I2 =94%,P<0. 000 01)among the different studies. Based on the classification of hospital type and different areas, the results of sub-group analysis showed the differences of study methods in the literatures and regional implementation measures of EDP contributed to the high heterogeneity among the different studies. Con-clusion:In order to reduce the heterogeneity of studies, a unified evaluation criteria for the research quality of the cross-section survey should be established. And special policies related to EDP should be taken to effectively decrease the use rate of antibiotics in primary hospitals.
