Study on the Quality Standard for Naoxin Luotong Pills
- VernacularTitle:脑心络通丸的质量标准
- Author:
Yin LU
;
Yinjuan WANG
;
Lu HUANG
;
Ru BAI
;
Hua SU
;
Haiyang REN
- Publication Type:Journal Article
- Keywords:
Naoxin Luotong pills;
Quality standard;
Microscopic identification;
TLC;
HPLC;
Total ferulic acid
- From:
China Pharmacist
2016;19(4):776-780
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To establish the quality standard for Naoxin Luotong pills. Methods:Astragali radix, bombyx batryticatus and scorpio were identified under a microscope. Peach kernel, astragali radix, paeoniae radix alba, rheum, paeonia suffruticosa and salvia miltiorrhiza were identified by TLC. The content of total ferulic acid was determined by HPLC with a Sapphire C18 column (250 mm × 4. 6 mm,5 μm). The mobile phase was acetonitrile-0. 1% phosphoric acid(12 ∶88)and the detection wavelength was 316 nm. The column temperature was 35℃ and the flow rate was 1. 0 ml·min-1 . Results:The microscopic characteristics of astragali radix, bombyx batryticatus and scorpio were obvious to be observed easily. The TLC spots of peach kernel, astragali radix, paeoniae radix al-ba, rheum, paeonia suffruticosa and salvia miltiorrhiza were clear and specific. Ferulic acid had a good linear relationship within the range of 5. 1-81. 6μg·ml-1(r=0. 999 9), and the average recovery was 103. 30% with RSD of 1. 96% (n= 9). Conclusion:The standard can be used for the quality control of Naoxin Luotong pills.
