Study on Laxative Effect of Xianchang Tea in Mice
- VernacularTitle:纤畅茶对小鼠通便作用考察
- Author:
Lei HUANG
;
Xianwu XU
;
Jing CHENG
- Publication Type:Journal Article
- Keywords:
Xianchang tea;
Mice;
Constipation model
- From:
China Pharmacist
2016;19(4):817-819
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the laxative effect of Xianchang tea in mice. Methods:The mice were randomly divided into the blank control group, the model control group, the low dose group, the medium dose group and the high dose group(2. 275 g·kg-1, 4. 55 g·kg-1 and 13. 65 g·kg-1). The mice were treated with 0. 9% normal saline solution or Xianchang tea through intragastric ad-ministration once a day for 14 days. The mice in the model control group and the three dose groups were established the constipation model with compound diphenoxylate. The weight of mice, small intestine motor and defecation effect after the 6-hour administration were observed. Results:The small intestine motor experiments showed that the ink-impelling ratio of the high dose group was increased (P<0. 05) and the time of the first ink defecation was shorter (P<0. 05). The feces weight in 4. 55 and 13. 65 g·kg-1 dose groups were increased (P<0. 05). The feces quantity of the three dose groups showed no significant difference when compared with that of the control group (P>0. 05). Conclusion:Xianchang tea has a positive laxative effect in mice.
