Formula Optimization of Ropivacaine Hydrochloride Transdermal Gel
- VernacularTitle:盐酸罗哌卡因透皮凝胶剂的处方优化
- Author:
Rui XIONG
;
Xudong FU
;
Mengying LUO
;
Lian XU
- Publication Type:Journal Article
- Keywords:
Ropivacaine hydrochloride;
Gel;
Orthogonal design;
Transdermal drug delivery
- From:
China Pharmacist
2016;19(4):660-664
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To optimize the formula of ropivacaine hydrochloride transdermal gel. Methods:The steady transdermal rate and cumulative transdermal percentage in 24 h of ropivacaine hydrochloride gel were used as the indices, an orthogonal design was applied to select the optimal formula, and Design Expert 8. 0. 5. 0 software was used to analyze the results. Results: The optimal formula con-tained 2% carbomer, 10% propylene-glycol and 5% Azone. The steady transdermal rate of the optimal formula was 0. 6951 mg·h-1 · cm-2 . The cumulative transdermal percentage in 24 h of the optimal formula was 91. 04%, which was 22. 79% higher than that of ropiva-caine hydrochloride solution with the same concentration. Design Expert 8. 0. 5. 0 software could predict the steady transdermal rate and cumulative transdermal percentage in 24 h of the optimal formula. Conclusion: The preparation design is reasonable, and the gel has promising properties, which is suitable for skin local application.
