The relationship between plasma D-dimer and coronary slow flow in patients with acute coronary syndrome after percutaneous coronary intervention
10.3760/cma.j.issn.1671-0282.2016.04.016
- VernacularTitle:急性冠脉综合征患者介入术后慢血流事件与血浆 D-二聚体水平关系
- Author:
Hailong GE
;
Dongmei SHI
;
Jianlong WANG
;
Hongya HAN
;
Xiaoli LIU
;
Qian MA
;
Yujie ZHOU
- Publication Type:Journal Article
- Keywords:
D-dimer;
Coronary slow flow;
Acute coronary syndrome;
Percutaneous coronary intervention;
Risk factors;
Prognosis
- From:
Chinese Journal of Emergency Medicine
2016;25(4):475-478
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the correlation between the risk factors of coronary slow flow phenomenon ( CSF) and the level of plasma D-dimer in patients with ACS ( acute coronary syndrome) after emergency percutaneous coronary intervention ( PCI) .Methods A total of 297 patients with ACS after PCI were enrolled for retrospective analysis.All patients were divided into CSF group and control group in the light of corrected thrombolysis in myocardial infarction (TIMI) frame count method (cTFC).Multivariate analysis for evaluating clinical predictors of CSF was carried out using Logistic regression test and Pearson analysis to find the correlation between plasma D-dimer and cTFC.The predictive value of D-dimer level in the occurrence of coronary slow flow was determined by using receiver operating characteristic ( POC) curve analysis.Results CSF was observed in 59 cases (19.8%).The plasma D-dimer was significantly higher in the coronary slow flow group compared with the control group ( P <0.05 ) .Multivariate regression analysis and Logistic regression test showed that the level of plasma D-dimer ( OR =1.276, 95%CI:1.132-3.224, P=0.012), thrombus score (OR =1.108, 95%CI: 1.085-2.103, P =0.018) and target lesion length of culprit vessel ( OR =1.436, 95%CI: 0.635-1.382, P =0.037 ) were the risk factors of CSF.Correlation analysis showed that plasma D-dimer were positively associated with CSF. Receiver operating characteristic ( ROC ) curve analysis showed that D-dimer cutoff point at 515.3 ng/ml had a good judgment significance ( AUC 0.783, OR =1.502, 95%CI: 1.324-2.531, P =0.005). Conclusions The increased D-dimer level is a risk factor and plays an important role in the ACS patients with the CSF phenomenon, thereby predicting no-reflow phenomenon after primary PCI in these patients.
