Effect of Regular Exercise during Recovery Period Following Steroid Treatment on the Atrophied Type II Muscles Induced by Steroid in Young Rats.
10.4040/jkan.2002.32.4.550
- Author:
Myoung Ae CHOE
1
;
Gi Soo SHIN
;
Gyeong Ju AN
;
Jung An CHOI
;
Yoon Kyong LEE
Author Information
1. College of Nursing, Seoul National University, Korea.
- Publication Type:Original Article
- Keywords:
Exercise;
Steroid;
Fast-twitch muscle fibers
- MeSH:
Animals;
Body Weight;
Dexamethasone;
Muscle Fibers, Fast-Twitch;
Muscles*;
Muscular Atrophy;
Rats*;
Weights and Measures
- From:
Journal of Korean Academy of Nursing
2002;32(4):550-559
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: This study was conducted to determine whether low intensity regular exercise following dexamethasone treatment could attenuate steroid-induced muscle atrophy. METHOD: 36 Wistar-rats(90-110g) were divided into six groups: control group(C), dexamethasone treatment group(D), sedentary group after normal sedentary period(C+S), sedentary group after dexamethasone treatment period(D+S), exercise group after normal sedentary period(C+E), and excercise group after dexamethasone treatment period(D+E). D, D+S, and D+E groups received dexamethasone injection(5mg/Kg) for seven days whereas C, C+S, and C+E groups received normal saline injection. Both C+E and D+E groups ran on a treadmill for 60 minutes/day(20minutes/4hours) at 15m/min and a 10degreegrade for seven recovery days. RESULT: Post-weight(body weight before muscle dissection) of D group significantly decreased by 16.03%, and that of D+E group significantly increased by 15.51% compared with pre-weight(body weight before steroid treatment). Type II muscle(plantaris and gastrocnemius) weights of D group were significantly lower than those of C group. Myofibrillar protein contents of type II muscles of D group tended to decrease comparing with C group. In D+E groups, body weights and relative weights of typeII muscles(muscle weight(mg)/post-weight(g)) tended to increase comparing with D+S group. CONCLUSION: It is suggested that steroid- induced muscle atrophy can be ameliorated through low intensity regular exercise after dexamethasone treatment.
