Research progress of biomarkers of acute respiratory distress syndrome

VernacularTitle:急性呼吸窘迫综合征的生物标志物研究进展
Author: Yanli GUO ; Ying QIU ; Manqiu CHEN
Publication Type:Journal Article
From: Chinese Journal of Emergency Medicine 2016;25(4):542-545
CountryChina
Language:Chinese
Abstract: ARDS is a type of acute diffuse lung injury, characterized by inflammation leading to increased pulmonary vascular permeability and loss of aerated lung tissue, the clinical manifestations are refractory hypoxia, progressive respiratory distress and non cardiac pulmonary edema.ARDS mortality rate is very high, especially in patients with severe ARDS, about 27%-45%. In order to improve diagnostic specificity, a revised definition was published in JAMA in 2012, but no new biomarkers or parameters were adopted.Along with the progress in understanding the pathophysiology of ARDS, a variety of humoral factors by inflammation and molecules derived from injured tissues or activated cells may be potential biomarkers for clinical.