Expressions of phosphorylated c-Jun N-terminal kinase and P38 mitogen-activated protein kinase in psoriasis vulgaris lesions
10.3760/cma.j.issn.0412-4030.2016.04.005
- VernacularTitle:磷酸化 c-Jun 氨基末端激酶和 P38丝裂原活化蛋白激酶在寻常性银屑病皮损中的表达
- Author:
Xinhong GE
;
Zhenzhen TANG
;
Yaning JIAO
;
Hao WU
;
Nan YU
;
Lingdi DONG
;
Le LI
;
Biao YANG
;
Xiaoxia PU
- Publication Type:Journal Article
- Keywords:
Psoriasis;
JNK mitogen-activated protein kinases;
p38 mitogen-activated protein kinases;
C-Jun N-terminal kinase
- From:
Chinese Journal of Dermatology
2016;49(4):248-251
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate expressions of phosphorylated c-Jun N-terminal kinase (p-JNK)and P38 mitogen-activated protein kinase(p-P38MAPK)in psoriasis vulgaris lesions. Methods Tissue specimens were obtained from lesions of 30 patients with psoriasis vulgaris and normal skin of 30 healthy human controls. An immunohistochemical study and Western-blot analysis were performed to measure protein expressions of p-JNK and p-P38MAPK in these skin specimens. Results As the immunohistochemical study showed, the expressions of p-JNK and p-P38MAPK(expressed as the average optical density [AOD]value for targeted proteins)were significantly higher in psoriasis vulgaris lesions than in normal skin tissues (p-JNK: 0.663 ± 0.016 vs. 0.333 ± 0.009, t = 44.869, P < 0.001; p-P38MAPK: 0.436 ± 0.011 vs. 0.306 ± 0.010, t = 21.913, P < 0.001). Western-blot analysis also showed increased protein expressions of p-JNK and p-P38MAPK in psoriasis vulgaris lesions compared with normal skin tissues (t = 20.477, 165.084, respectively, both P <0.05). Conclusion The activation of JNK and P38MAPK may be involved in the overproliferation of epidermal cells in psoriasis vulgaris lesions.
