Verification of conserved domain peptides derived from human antimicrobial peptide hGlyrichin
10.7644/j.issn.1674-9960.2016.03.014
- VernacularTitle:人源性抗菌肽hGlyrichin中保守结构域肽段功能验证
- Author:
Jibin SHA
;
Guang ZHAO
;
Chenggang ZHANG
- Publication Type:Journal Article
- Keywords:
cathelicidins;
antimicrobial peptides;
hGlyrichin;
conserved domain;
hemolysis
- From:
Military Medical Sciences
2016;40(3):221-225
- CountryChina
- Language:Chinese
-
Abstract:
Objective To verify the antibacterial activity of the conserved domain derived from the novel human antimicrobial peptide-hGlyrichin .Methods Bioinformative analysis was performed and two peptides derived from hGlyrichin were synthesized which contained the conserved domain .Results Analysis of antimicrobial activities showed that these two peptides exhibited strong antibacterial activity which was inversely proportional to the length of the peptide within an eligible range.Despite the effective inhibition and killing of bacteria , the synthetic peptide segments had no hemolytic effect on human red blood cells .Conclusion These results indicate that a conserved domain exists in hGlyrichin , and that the peptides which contain this domain have strong antibacterial activity but are not toxic to human somatic cells .
