Expression of MTSS1 in cervical cancer tissue and its clinical significance
10.7644/j.issn.1674-9960.2016.03.018
- VernacularTitle:宫颈癌中MTSS1基因的表达及其临床意义
- Author:
Si ZHANG
;
Yuanlin LIU
;
Xiangdong ZHOU
;
Yue ZHAO
;
Ying TONG
;
Yi ZHANG
- Publication Type:Journal Article
- Keywords:
uterine cervical neoplasms;
metastasis suppressor1(MTSS1);
gene expression;
clinical stages
- From:
Military Medical Sciences
2016;40(3):237-240
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect the expression of metastasis sappressor 1(MTSS1) gene in cervical cancer tissue and to clarify its association with cervical cancer.Methods Totally 103 cases of cervical tissue were collected between Dec 2011 and Dec 2014 and classified according to biopsy and stage .Q-PCR and Western blotting were used to detect the expression of MTSS1 in normal cervical tissue and in different clinical stages of cervical cancer tissue .Results The expression of MTSS1 inⅡB-Ⅳstages of cervical cancer tissue was significantly higher than that of normal tissue or Ⅰ-ⅡA stages through q-PCR (P=0.000).Western blotting results showed that MTSS1 was positively expressed in normal cervical tissue at a rate of 23.3% or 53.3% in cervical cancer tissue.Moreover, the expression of MTSS1 was poorly correlated with age, tumor differentiation and lymphnode metastasis in cervical cancer tissue (P>0.05).The protein level of MTSS1 expressed in ⅡB-Ⅳ stages was significantly higher than that ofⅠ-ⅡA stages(P=0.005).Conclusion The expression of MTSS1 indicates the clinical stage of cervical cancer , suggesting that MTSS1 may play an important role in the development of cervical cancer .
