The role of CDC42 in cancer
10.7644/j.issn.1674-9960.2016.03.023
- VernacularTitle:CDC42与癌症
- Author:
Yongru XU
;
Ping XU
;
Feng XU
;
Xiangping LI
- Publication Type:Journal Article
- Keywords:
CDC42;
cancer;
cell transformation;
neoplasms
- From:
Military Medical Sciences
2016;40(3):256-260
- CountryChina
- Language:Chinese
-
Abstract:
Cell division cycle 42 (CDC42)is a member of Rho guanosine triphosphatase (GTPase) family,which plays an important role in cell proliferation , cell migration and cell transformation .The activity of CDC42 can be regulated by guanine nucleotide exchange factors (GEFs),GTPase activating proteins (GAPs) and guanine nucleotide-dissociation inhib-itors (GDIs).Recently,CDC42 has been reported as abnormally expressed in many human cancers ,suggesting that CDC42 performs complex functions in tumorigenesis .Therefore,this paper aims to shed light on the functions of CDC 42 in cancers in terms of the alteration of CDC42 activity,CDC42 regulators,as well as its effectors.
