Progress in vaccine development of Marburg virus
10.7644/j.issn.1674-9960.2016.03.024
- VernacularTitle:马尔堡病毒疫苗研究进展
- Author:
Tuo LI
;
Zhuguo LIU
;
Qiuyun DAI
- Publication Type:Journal Article
- Keywords:
Marburg virus;
infection mechanism;
vaccines;
neutralizing antibody
- From:
Military Medical Sciences
2016;40(3):261-264
- CountryChina
- Language:Chinese
-
Abstract:
Marburg virus (MARV) is a member of the Filoviridae family and belongs to a non-segmented, single-strand and negative-sense RNA virus.Since the first discovery of virus in 1967, infections have broken out 14 times, causing the infection of 588 people and 482 deaths.The mortality is up to 82%.Marburg virus results in multiple organ infections , severe hemorrhagic fever and death .Currently, there are no available licensed vaccines or post-exposure treatment , but the vaccines have proved effective in experimental animals .This review briefly summarizes the structure , infection mechanism and the progress in vaccines of this virus .
