CD177+ neutrophils and its correlation with mucosal impairment in patients with inflammatory bowel disease
10.3760/cma.j.issn.1007-5232.2016.03.011
- VernacularTitle:CD177+中性粒细胞与炎症性肠病肠黏膜损伤关系的研究
- Author:
Yang SONG
;
Wenjing YANG
;
Guangxi ZHOU
;
Zhanju LIU
- Publication Type:Journal Article
- Keywords:
Neutrophil;
Antigens,CD177;
Inflammatory bowel disease;
Endoscopic disease activity index
- From:
Chinese Journal of Digestive Endoscopy
2016;33(3):178-182
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the percentage of CD177+ neutrophils in peripheral blood and inflamed mucosa of the intestine in patients with inflammatory bowel disease(IBD)and in healthy controls, and to investigate the correlation between CD177+ neutrophils and mucosal impairment as well as clinical characteristics. Methods A total of 54 patients with ulcerative colitis(UC),62 patients with Crohn disease (CD),and 48 healthy controls were enrolled. SYBR-green Realtime PCR was applied to determine the ex-pression proportion of CD177+ neutrophils in peripheral blood and in inflamed intestinal mucosa to investigate the correlation between CD177+ neutrophils and endoscopic and clinical disease activity. Results In periph-eral blood and inflamed mucosa of the intestine,the expression of CD177+ neutrophils was significantly higher than that in health controls or patients in remission stage(P< 0. 05),with higher proportion( P<0. 05). The expression of CD177+ neutrophils in peripheral blood and inflamed mucosa of the intestine was positively correlated with both endoscopic disease activity index and clinical severity of the disease( P <0. 05). Conclusion CD177+ neutrophils increase in peripheral blood and intestinal mucosa of patients with IBD. The percentage of CD177+ neutrophils is a favorable marker for both endoscopic disease activity and clinical severity of the disease. CD177+ neutrophils may play a vital role in the immune response in the intes-tinal mucosa,as a new subset of effector neutrophils.
