Clinical effect of bicyclol tablet on hepatic lesions caused by Epstein-Barr virus infetc ion in children
10.3760/cma.j.issn.1673-4912.2016.030.10
- VernacularTitle:双环醇治疗儿童 EB病毒感染所致肝功能损害的疗效观察
- Author:
Xu TENG
;
Lingfen XU
;
Mei SUN
;
Jing GUO
- Publication Type:Journal Article
- Keywords:
Children;
Hepatitis;
Epstein-Barr virus;
Bicyclol tablet
- From:
Chinese Pediatric Emergency Medicine
2016;23(3):182-185
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the efficacy and safety of bicyclol tablet on hepatic lesions caused by Epstein-Barr virus( EBV) infection in children.Methods A single-center controlled retrospective study was conducted in 121 children with hepatic lesions caused by EBV infection for evaluating safety,tolerability, and efficacy of treatment with bicyclol tablets or Glycyrrhizin capsules.Childer n in bicyclol group ( n=63 ) were treatedw ith bicyclol at blets and cotn rol group ( n =58 ) were treated with Glycyrrhizin capsules.The course of the treatment were both 8 weeeks for two groups.The level of the EBV load pretreatment and plas-ma aminotransferase,blood routine,urine routine pretreatment and 1 week,4 weeks and 8 weeks after treat-mentw ere analyzed er trospectively.Rse ults (1) The pal smaA LT level sigin ficantly decreased in theb icy-clol group compared with that in the contro l group(P<0.01), se pecai lly the levle after 8 weeks treatm ent. (2) Bicycol l was more effce tive in the bicyclol group than Glycyrrhizin capslu se in the control group( P<0.01).(3) Both grousp had no significantlya dvesr e events.Conclusion Bicyclol tablet can derc ease plas-ma aminotransferase level,espce ially ALT,inc hildren caused by EBV infection with better efficiency and safety.
