Values of G test and GM test combined with fungal culture method for diagnosis of invasive fungal infection in lungs
10.7644/j.issn.1674-9960.2016.03.017
- VernacularTitle:GM、G试验及真菌培养鉴定对肺部侵袭性真菌感染的诊断价值
- Author:
Qing MA
;
Nong YU
;
Xiuyun YIN
;
Xin JIN
;
Shuiping CHEN
;
Jiankui CHEN
- Publication Type:Journal Article
- Keywords:
invasive fungal infection;
bronchoalveolar lavage fluid;
diagnosis;
detection;
galactomannan;
(1,3)-β-D-glucan test;
fungal identification
- From:
Military Medical Sciences
2016;40(3):234-236
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic efficiency of deep fungal infection by detecting the serum galactomannan ( GM) and bronchoalveolar lavage fluid ( BALF) GM, serum G test and fungal culture of BALF in patients with suspected invasive fungal infection ( IFI) in lungs.Methods A retrospective analysis was performed of the results of serum /BALF GM test ,serum G test and BALF culture from 148 patients with suspected pulmonary IFI .The indexes involved sensitivity , specificity , positive predictive value , negative predictive value , as well as diagnostic capacity for deep fungal infection with separated or combined tests .Results Among the 148 cases, 48 cases were clinically diagnosed with IFI and the rest were excluded.Among the 48 IFI cases, 3 cases were positive in serum GM test , 25 cases were positive in BALF GM test , 31 cases were positive in G test and 30 cases were positive in fungal culture .The combined detection showed a sensitivity of 91.6%,specificity of 70.0%, positive predictive value of 59.5% and negative predictive value of 94.6%.Conclusion The combination of GM/G tests and fungal culture can significantly improve the clinical diagnostic efficiency of pulmonary IFI .
