Role of Wnt/β-catenin signaling pathway in atherosclerosis
10.3969/j.issn.1000-4718.2016.03.030
- VernacularTitle:Wnt／β-catenin通路在动脉粥样硬化发生发展中的作用
- Author:
Shouyuan MA
;
Shutong YAO
;
Ping ZHU
;
Shucun QIN
- Publication Type:Journal Article
- Keywords:
Wnt/β-catenin signaling pathway;
Atherosclerosis
- From:
Chinese Journal of Pathophysiology
2016;32(3):564-568
- CountryChina
- Language:Chinese
-
Abstract:
Atherosclerosis is a multifactorial process associated with endothelial cell injury and dysfunction , inflammation, oxidative stress, cell proliferation, angiogenesis and so on , all of which play a crucial role in atherosclerosis . Wnt/β-catenin signaling pathway is highly conservative in the development of body , abnormal activation of which is related to types of diseases including cancer .Accumulating studies have shown that Wnt/β-catenin signaling pathway is involved in inflammation, oxidative stress and so on .This article would make a review about the role of Wnt/β-catenin signaling path-way in atherosclerosis based on the pathogenic mechanisms underlying atherosclerosis as mentioned above .
