Progress on relationship between renin-angiotensin system and skeletal muscle insulin resistance
10.3760/cma.j.issn.1671-7368.2016.03.020
- VernacularTitle:肾素血管紧张素系统与骨骼肌胰岛素抵抗的关系
- Author:
Qi HUANG
;
Wenjun WU
;
Ruifang BU
- Publication Type:Journal Article
- Keywords:
Renin-angiotensin system;
Insulin resistance
- From:
Chinese Journal of General Practitioners
2016;15(3):228-231
- CountryChina
- Language:Chinese
-
Abstract:
Skeletal muscle is essential for the glucose disposal in organism, which is one of the major sites of insulin resistance.The over-activity of classical renin-angiotensin system ( RAS) induces the oxidative stress, leads to the impairment of insulin signaling and glucose transport, resulting in insulin resistance of skeleton muscle.The activation of non-classical RAS by inhibiting classical RAS activity, can ameliorate insulin resistance in skeletal muscle tissue.
