Analysis difference of lymphocyte subgroups between children with severe pneumonia and non-severe pneumonia
10.3969/j.issn.1000-484X.2016.03.023
- VernacularTitle:婴幼儿重症和非重症肺炎淋巴细胞亚群的差异分析
- Author:
Siqi LONG
;
Li MA
;
Min CHEN
;
Hong LI
- Publication Type:Journal Article
- Keywords:
Severe pneumonia;
T lymphocytes subsets;
CD19+B lymphocytes;
Cellur immunity
- From:
Chinese Journal of Immunology
2016;32(3):401-404
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To observe the levels of lymphocyte subgroups in children with severe pneumonia and non -severe pneumonia , and to investigate the change of celluer immune funciton of patients , moreover provide available reference for treatment.Methods:Flow cytometry instrument was used to detect peripheral blood CD 3+T, CD3+CD4+T, CD3+CD8+T, CD19+B lymphocytes and NK cells in 27 children with severe pneumonia and 28 children with non-severe pneumonia.In addition 20 heathy children were selected as the controls .Results:Compared with the heathy control group ,the levels of CD3+T,CD3+CD4+T,CD3+CD8+T lymphocytes and NK cells in children with severe pneumonia decreased significantly (P<0.01,P<0.05,P<0.01,P<0.05),while CD4/CD8 ratio,CD19+B cells were significantly increased (P<0.05,P<0.01).The level of CD3+CD8+T lymphocytes in children with non-severe pneumonia significantly lower than the heathy control group (P<0.01),but the level of CD19+B cells in children with non-severe pneumonia significantly higher than the heathy control group (P<0.01).Compared with non-severe pneumonia group.The levels of CD3+and CD3+CD8+T lymphocytes in children with severe pneumonia decreased significantly (P<0.01),however CD19+B cells were significantly increased ( P<0.01 ) .Conclusion: Immune dysfunction exists in both of children with severe pneumonia and non-severe pneumonia.Children with severe pneumonia has more serious damage in inmmunity .This provides certain theoretical basis for clinical e-valuation and treatment .
