Continuous blood purification in patients with severe sepsis:Is it magic?
10.3760/cma.j.issn.1673-4912.2016.03.005
- VernacularTitle:连续性肾脏替代疗法在重症脓毒症的应用--是魔弹吗？
- Author:
Yun CUI
;
Fei WANG
- Publication Type:Journal Article
- Keywords:
Severe sepsis;
Multiple organ dysfunction syndrome;
Continuous renal replacement therapy
- From:
Chinese Pediatric Emergency Medicine
2016;23(3):159-163
- CountryChina
- Language:Chinese
-
Abstract:
Continuous renal replacement therapy( CRRT) employs convection and adsorption to re-move pro-and anti-inflammatory mediators from plasma, helping to restore the immunologic homeostasis. CRRT also provide uninterrupted clearance of retained endogenous and exogenous toxins, along with acid-base,electrolyte,hemodynamics and volume homeostasis.CRRT may improve outcomes in critically ill pa-tients with sepsis-induced acute kidney injury,septic shock and multiple organ dysfunction syndrome.Region-al citrate anticoagulation, as compared to unfractionated heparin, report better filter survival times and less bleeding.Antibiotic dosing decisions should be individualized to take into account patient-related,CRRT-relat-ed,and drug-related factors.
