Research progress on the mechanism of transformation of myelodysplastic syndrome to acute myeloid leukemia
10.3760/cma.j.issn.1009-9921.2015.12.019
- VernacularTitle:骨髓增生异常综合征转化为急性髓系白血病机制的研究进展
- Author:
Dongsheng MA
- Publication Type:Journal Article
- Keywords:
Myelodysplastic syndromes;
Leukemia,myeloid,acute;
Cell transformation,neoplasms;
Pathogenesis
- From:
Journal of Leukemia & Lymphoma
2015;24(12):765-768
- CountryChina
- Language:Chinese
-
Abstract:
Myelodysplastic syndrome (MDS) is a group of clonal diseases originating from hematopoietic stem/progenitor cells with high risk of transformation to acute myeloid leukemia (AML).Due to the lack of effective treatment after transformation into AML and the poor prognosis, now the bone marrow transplantation is the only way to cure this disease, but only a few of patients are suitable for transplantation.So the study on the mechanism of transformation of MDS to AML is important for development of effective drugs are.This paper presents a review of the latest update on mechanism of transformation of MDS to AML.
