Research progress on biological behavior and molecular mechanism of histological transformation in follicular lymphoma

VernacularTitle:滤泡性淋巴瘤转化的生物学行为及其分子机制研究进展
Author: Heng LI
Publication Type:Journal Article
Keywords: Lymphoma,follicular; Cell transformation,neoplasms; Molecular mechanism
From: Journal of Leukemia & Lymphoma 2015;24(12):762-764
CountryChina
Language:Chinese
Abstract: A variety of inert non Hodgkin' s lymphoma were converted into the risk of aggressive non Hodgkin' s lymphoma, especially in follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL).The histological transformation is not an event driven by a single factor, but is the clonal evolution process of a variety of mechanisms.This article reviews the biological behavior of the transformation from the high risk factors, the evolution mode of cloning and the molecular mechanism of the occurrence of the transformation.