Evaluation of parameters for predicting the response to clomiphene citrate in women with polycystic ovary syndrome
10.3760/cma.j.issn.1008-1372.2015.12.016
- VernacularTitle:预测多囊卵巢综合征患者对克罗米芬反应性指标的分析
- Author:
Hui MAO
;
Wenyan XI
;
Yongkang YANG
;
Xiang XUE
;
Shengyu FU
- Publication Type:Journal Article
- Keywords:
Polycystic ovary syndrome/TH/US;
Clomiphene/TU;
Menstrual cycle;
Ovarian follicle
- From:
Journal of Chinese Physician
2015;17(12):1823-1826
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate whether clinical,endocrine,and sonographic characteristics of infertile women with polycystic ovary syndrome (PCOS) could predict the ovarian response to clomiphene citrate (CC) medication.Methods A prospective study was conducted,85 women with PCOS were given CC 50 mg per day for 5 days.In the case of an absent response,doses were increased to 100 daily in subsequent cycles.Clinical,endocrine,and sonographic characteristics were compared between responders and nonresponders.Results The cycle history (oligomenorrhea or amenorrhea) and antral follicle count (AFC) were significantly different in responders from those in nonresponders (P ＜ 0.05).There were no differences in age,serum testosterone,follicle stimulating hormone (FSH),luteotropic hormone (LH),body mass index (BMI),insulin resistant index (HOMA-IR),and glucose and insulin levels between the two groups (P ＞ 0.05).In addition,multivariate logistic regression analysis indicated that cycle history and AFC were the predictors of ovarian response to CC treatment.Conclusions The cycle history and AFC can be used as the simple and effective parameters to predict ovarian response to CC treatment in PCOS patients.
