Preventive effect of low-dose sufentanil combined with parecoxib sodium for hyperalgesia of remifentanil anesthesia after postoperative
10.3760/cma.j.issn.1008-1372.2015.12.015
- VernacularTitle:小剂量舒芬太尼联合帕瑞昔布钠对瑞芬太尼麻醉术后痛觉过敏的预防效应
- Author:
Caiping LIAO
- Publication Type:Journal Article
- Keywords:
Sufentanil/AD;
Cyclooxygenase 2 inhibitors/AD;
Fentanyl/TU;
Anesthesia;
Hyperalgesia/PC
- From:
Journal of Chinese Physician
2015;17(12):1820-1822
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore preventive effect of low-dose sufentanil combined with parecoxib sodium for hyperalgesia of remifentanil anesthesia after postoperative.Methods A total of 120 patients undergoing elective abdominal surgery under general anesthesia was randomly divided into three groups that were given intraoperative remifentanil infusion.At the 30 minutes before surgery,group A were given intravenous sufentanil 0.1 μg/kg combined with 40 mg parecoxib sodium,group B were given intravenous sufentanil 0.2 μg/kg combined with 40 mg parecoxib sodium,and group C were given normal saline 5 ml.Postoperative recovery time,extubation time,postoperative 1,2,6,12,and 24 h visual analog scale (Visual Analogue Scale/Score,VAS) score,and after 24 h additional analgesia number of cases and the restless occurrence of three groups were compared.Results Awakening time and extubation time of group B was significantly longer than groups A and C [(10.9 ± 1.3) min vs (8.6 ± 0.6) min,(8.2 ± 0.7) min;(14.0 ± 2.1) min vs (10.7 ± 2.2) min,(10.8 ± 1.2) min,all P ＜ 0.01].Each point VAS scores of groups A and B were significantly lower than group C (P ＜0.01).After 24 h,the number of cases additional analgesic medication,and restlessness occurrence of group C were significantly more than the number of cases of groups A and B (P ＜ 0.01),the number of cases and the restless occurrence after 24 h additional analgesic drugs of group A were more than group B,but there was no significant difference between two groups (P ＞ 0.05).Conclusions Low dose sufentanil together with parecoxib sodium can inhibit after-remifentanil-induced hyperalgesia,and will not appear awakening time and extubation time delays and safe.
