Study on relationship between single nucleotide polymorphisms polymorphisms of DDC and DRD1 and clinical phenotype feature in autistic children
10.3760/cma.j.issn.1008-1372.2015.12.009
- VernacularTitle:DDC与DRD1基因单核苷酸多态性与儿童孤独症临床表型特征的相关性研究
- Author:
Jun LIU
;
Hong YU
;
Aiping YANG
;
Guohui YANG
;
Wenjun YANG
;
Zengyu ZHANG
- Publication Type:Journal Article
- Keywords:
Dopa decarboxylase/GE;
Receptors,dopamine/GE;
Autistic disorder/GE
- From:
Journal of Chinese Physician
2015;17(12):1797-1800
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the association between single nucleotide polymorphisms (SNPs) of DOPA decarboxylase (DDC) and dopamine receptor-1 (DRD1) and clinical phenotype feature in autistic children.Methods TaqMan probes real-time polymerase chain reaction (PCR) was used to determine genotype and allele of SNPs of DDC gene (rs6592961) and DRD1 (rs251937) gene in 97 autism children.The Children Autism Rating Scale (CARS) was used to evaluate clinical phenotype feature.Results There was no significant difference in the distribution of the allelic frequency and genotype between mild-medium group and severe group of CARS scores (P ＞ 0.05).For DDC gene (rs6592961),significant difference was found in subscale between genotypes G/G and A/A (P =0.043).For DRD1 gene (rs251937),significant difference was found in subscale between genotypes T/T and C/C (P =0.029).Conclusions In DDC gene (rs6592961),the children with G/G genotype were more obvious than the children with A/A genotype.In DRD1 gene (rs251937),the children with T/T genotype were more obvious than the children with C/C genotype.
