Prognosis of patients with unstable angina in PCI adverse events factor analysis and the function of CYP2C19 gene mutations
- VernacularTitle:不稳定型心绞痛患者经皮冠状动脉介入术预后不良事件因素分析及CYP2C19基因突变的作用
- Author:
Ying ZHU
;
Lili GONG
;
Lihong LIU
- Publication Type:Journal Article
- Keywords:
CYP2C19genotype;
Unstable angina;
Aspirin;
Clopidogrel;
The prognosis
- From:
Chinese Journal of Postgraduates of Medicine
2015;38(z1):90-93
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the prognosis of patients with unstable angina in PCI adverse events factor analysis,and the function of CYP2C 19 gene mutations.Methods From May 2013 to May 2015,226 cases of PCI postoperative patients,after surgery all took aspirin + clopidogrel maintenance to treat for 1 years,analyzed CYP2C19*1,CYP2C19*2,CYP2C19 *3 genotype with fluorescent polymerase chain reaction (PCR),the patients were followed up for 6 months.According to the result of detection of genotype divided into wild type group (CYP2C19 *1/*1),the mutation of mixed group (CYP2C19 *1/*2 and CYP2C19 *1/*3) group and mutations in pure form group (CYP2C19 *2/*2 and CYP2C19 *3/*3).Observed the occurrence of unstable angina of three groups prognosis.Results The mutation of mixed to form and mutation of pure form had a record of hospital clinical adverse events (61.9％ and 45.3％) was significantly higher risk of wild group (42.4％),with statistical significance (P ＜0.05);Logistic regression analysis of diabetes and CYP2C19 genotype with PCI postoperative patients with unstable angina occurred in hospital records of clinical adverse events had good correlation (R =3.424,P=0.009 and R =5.679,P =0.001).Conclusion The CYP2C19 gene mutations and diabetes patients with unstable angina PCI postoperative prognosis is closely related,the lack of CYP2C19 gene type are more likely to affect the prognosis of unstable angina,provide reliable basis for further research.
