Correlation between copeptin and the disease severity, outcome and stress hyperglycemia in severe pneumonia patients
10.3760/cma.j.issn.1671-0282.2016.03.017
- VernacularTitle:重症肺炎患者copeptin与病情严重性、预后及应激性高血糖的关系
- Author:
Xijiang ZHANG
;
Tongwa CAO
;
Feng ZHAO
- Publication Type:Journal Article
- Keywords:
Copeptin;
Severe pneumonia;
APACHE Ⅱ;
Prognosi;
Stress hyperglycemia
- From:
Chinese Journal of Emergency Medicine
2016;25(3):338-342
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the changes of plasma copeptin level in pneumonia patients and to explore the correlation between copeptin and disease severity,outcome as well as stress hyperglycemia.Methods A total of 45 patients with severe pneumonia were included in a prospective observation.The plasma levels of copeptin,CRP and blood glucose were measured after admission,and the APACHE Ⅱ scores were recorded within 24 hours.The patients were given insulin therapy by intravenous micro-dosage pump,and the total doses of insulin were recorded.All the patients with 28-day survival were followed up.Results The plasma levels of copeptin of severe pneumonia patients after admission were positively correlated with APACHE Ⅱ (r =0.481,P =0.001) and blood glucose (r =0.417,P =0.004),and were also correlated with the total insulin doses in patients under insulin therapy (blood glucose ≥ 10.0 mmol/L).The plasma levels of copeptin of the survival group were significanatly higher than the non-survival group,COX regression multivariate analysis showed that copeptin was an independent risk factor of death in severe pneumonia patients (P =0.005,OR =1.022,95％ CI:1.00-1.044),and the area under the ROC curve was 0.740 9 (P =0.006).Conclusion The plasma levels in all patients with copeptin of severe pneumonia after admission is positively correlated with APACHE Ⅱ and stress hyperglycemia,suggesting a useful approach to the judgment of disease severity,outcome and glucose control.
