Serum micronutrients levels and clinical features of elderly asthmatics.
10.4168/aard.2017.5.4.223
- Author:
So Hee LEE
1
;
Woo Jung SONG
;
Heung Woo PARK
;
Sae Hoon KIM
;
Hye Kyung PARK
;
Sang Heon KIM
;
Yong Eun KWON
;
Tae Bum KIM
;
Byung Jae LEE
;
Young Koo JEE
;
Byoung Whui CHOI
;
Sang Heon CHO
;
Sun Sin KIM
Author Information
1. Departement of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. kimss@snu.ac.kr
- Publication Type:Original Article
- Keywords:
Elderly;
Asthma;
Micronutrients
- MeSH:
Aged*;
Asthma;
Folic Acid;
Forced Expiratory Volume;
Humans;
Immunoglobulin E;
Micronutrients*;
Minerals;
Miners;
Prevalence;
Vitamin D;
Vitamins
- From:Allergy, Asthma & Respiratory Disease
2017;5(4):223-227
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
PURPOSE: The prevalence of asthma in the elderly is rapidly increasing. However, we do not fully understand the pathogenesis of elderly asthma, especially for the roles of micronutrients. This study aimed to evaluate the associations between serum levels of micronutrients, including several vitamins and minerals, and clinical features of the elderly asthmatics. METHODS: A total of 317 asthmatics aged 65 or older were enrolled. Serum levels of vitamin D, vitamin B₁₂, folate, Mg, and Se were measured and then the associations between serum micronutrient levels and clinical features of elderly asthmatics were evaluated. RESULTS: Positive correlations with significance among serum levels of vitamin B₁₂, vitamin D, and folate were found. Serum micronutrients levels showed no difference according to the atopic status and symptom severity. The serum folate level was significantly associated with forced expiratory volume in 1 second, and serum vitamin B₁₂ and folate levels were significantly associated with serum total IgE level. Interestingly, elderly asthmatics with exacerbation history showed significantly lower serum levels of vitamin D and Mg, but significantly higher serum levels of Se. CONCLUSION: Serum levels of micronutrients, such as vitamin D, vitamin B₁₂, Mg, folate, and Se, were significantly associated with some clinical features of elderly asthmatics. Clinical meanings of these associations need to be investigated further.
