Expression of cadherin genes in chronic myeloid leukemia and its significance

VernacularTitle:钙黏蛋白相关基因在慢性粒细胞白血病中的表达及其作用
Author: Hongqin GAO ; Jingyu WEI ; Hua YAN ; Jianbin YANG
Publication Type:Journal Article
Keywords: Leukemia,myeloid,chronic; Cadherins; Gene
From: Journal of Leukemia & Lymphoma 2015;24(11):672-675
CountryChina
Language:Chinese
Abstract: Objective To explore the expression of cadherin (Cad) genes in patients with chronic myeloid leukemia (CML),and to elucidate the significance of Cad genes in the development of CML.Methods E-Cad and N-Cad gene expression levels in bone marrow mononuclear cells (BM-MNC) from 48 CML patients (29 in chronic phase,19 in progressive phase) were detected by real time quantitative polymerase chain reaction (qRT-PCR).Results Gene expression of E-Cad and N-Cad was detectable in CML BM-MNC.E-Cad gene expression level was lower in progressive CML than that in chronic CML (0.20 ± 0.35 vs 1.19 ± 0.87,P ＜ 0.01),while N-Cad was highly expressed in progressive CML than in chronic CML (0.89 ± 0.45 vs 0.57 ± 0.47,P ＜ 0.05).E-Cad gene expression level was negatively corrclatcd with thc pcrccntagc of peripheral blood progenitor cells (r =-0.705,P ＜ 0.01).Conclusion E-Cad and N-Cad gene expression correlates with the progression of CML,and might be used as an evaluation index for disease development.