Expression of TAK1 and p38 genes in patients with acute myeloid leukemia and their clinical significance
10.3760/cma.j.issn.1009-9921.2015.11.005
- VernacularTitle:急性髓系白血病患者TAK1、p38基因表达及其临床意义
- Author:
Fangfang YUAN
;
Ruihua MI
;
Lin CHEN
;
Xudong WEI
- Publication Type:Journal Article
- Keywords:
Leukemia,myeloid,acute;
Gene,TAK1;
Gene,p38
- From:
Journal of Leukemia & Lymphoma
2015;24(11):658-661
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression levels of TAK1 and p38 genes among different subtypes of acute myeloid leukemia (AML) patients,and to analyze the clinical characteristics of patients with different expression levels of TAK1 and p38 genes.Methods GAPDH was made as an internal reference,14 healthy people as control group.The quantitative real-time PCR was used to detect the expression of TAK1 and p38 in bone marrow samples of 87 AML patients,and the results were analyzed statistically.Results The expression levels of TAK1 and p38 in experiment group were higher than those in control group (0.194± 0.125 vs 0.015±0.008,0.233±0.140 vs 0.010±0.005,P ＜ 0.001).TAK1 expression in M4 was higher than that in M2,M3 and M5 (P =0.005,0.000,0.002),TAK1 expression in M3 was lower than that in M2 (P =0.022).p38 expression in M4 was higher than that in M1,M2,M3 and M5 (P =0.013,0.035,0.000,0.045),as it was higher in M2 and M5 than that in M3 (P =0.001,0.012).The CD56 positive rate cells and the number of peripheral blood leukocytes of the TAK1 high expression group were higher than those of the TAK1 low expression group,the CD19 positive rate of the p38 low expression group was higher than that of the p38 high expression group.Conclusion The expression levels of TAK1 and p38 genes are elevated in AML patients,and the up-regulation may play an important role in the pathogenesis of AML.
