Progress on metastasis induced by myeloid-derived suppressor cells to promote circu-lating tumor cell
10.3969/j.issn.1000-8179.2016.11.203
- VernacularTitle:髓源性抑制细胞促进循环肿瘤细胞形成转移的研究进展
- Author:
Bin LUO
;
Zujun QUE
;
Jianhui TIAN
- Publication Type:Journal Article
- Keywords:
metastasis;
circulating tumor cells;
myeloid-derived suppressor cells;
tumor microenvironment;
immune escape
- From:
Chinese Journal of Clinical Oncology
2016;43(11):493-497
- CountryChina
- Language:Chinese
-
Abstract:
Circulating tumor cells (CTCs), as the seeds of tumor metastasis, manage to escape from immune clearance both in microen-vironment and in peripheral blood. CTCs can also facilitate formation of pre-existing environment, which is the crucial step in metasta-sis. Myeloid-derived suppressor cells (MDSC), as a group of immunosuppressive cells derived from bone marrow cells, may play a key role in this process. In this review, the progress in MDSC and its role in the formation, survival, and immune escape of CTCs were exten-sively discussed to explore a new target for tumor immunotherapy.
