Research progress on the circadian clock gene PER in tumors
10.3969/j.issn.1000-8179.2016.10.352
- VernacularTitle:时钟基因PER在肿瘤中的研究进展
- Author:
Jinhao YANG
;
Ping WANG
- Publication Type:Journal Article
- Keywords:
circadian clock;
PER gene;
cancer suppressor;
radiotherapy;
chemotherapy
- From:
Chinese Journal of Clinical Oncology
2016;43(10):446-450
- CountryChina
- Language:Chinese
-
Abstract:
Circadian clock governs 24-hour rhythms in body temperature, blood pressure, circulating hormones, metabolism, and oth-er physiological parameters in humans and most mammals. The circadian clock is regulated by circadian clock genes. For instance, peri-od (PER) is a core circadian clock gene. Human PER includes PER1, PER2, and PER3, which play a role in cancer suppression. Abnormal PER expression not only causes cancer but also changes cellular sensitivity to radiation and chemotherapeutic drugs. Thus, this theory has provided a new direction for cancer radiotherapy and chemotherapy. This paper presents the research progress on PER in tumors.
