Research progress in molecular structure and function of nuclear factor erythroid 2 related factor 2 and Keap1 and regulation mechanism of signal pathways
10.3867/j.issn.1000-3002.2016.05.018
- VernacularTitle:核转录因子E2相关因子2和Keap1的分子结构和功能及其信号通路调控分子机制研究进展
- Author:
Zhaoyang WANG
;
Li JING
- Publication Type:Journal Article
- Keywords:
nuclear factor erythroid 2 related factor 2;
oxidative sress;
antioxidant response ele-ment;
regulation mechanism
- From:
Chinese Journal of Pharmacology and Toxicology
2016;30(5):598-604
- CountryChina
- Language:Chinese
-
Abstract:
The binding of the nuclear factor erythroid 2 related factor 2(Nrf2)to the antioxidant response elements(ARE)can start the expression of batches of antioxidant proteins,anti-inflammatory factors and detoxification enzymes. Nrf2/ARE signalling plays a pivotal role in anti-inflammation and in preventing xenobiotics induced lesions. Besides involvenment in physiological processes,such as regulating nutrient metabolism,Nrf2/ARE signalling also functions in the pathogenesis of various dieases. This review outlines the strcuture,functions,and regulation of Nrf2/ARE signal pathways.
