Study on effect of MMP-9 and HIF-1αexpression in nasal NK/T cell lymphoma
10.3969/j.issn.1000-484X.2016.06.020
- VernacularTitle:MMP-9及HIF-1α在鼻NK/T细胞淋巴瘤表达中的作用研究
- Author:
Huamei WEI
;
Kunping LIU
;
Chunying LUO
;
Yunlong LU
;
Yongyi HUANG
;
Qunying SU
;
Haishan LU
- Publication Type:Journal Article
- Keywords:
Nasal NK/T cell lymphoma;
Matrix metal loproteinase-9;
Hypoxia inducible factor alpha-1;
Clinical pathological characteristics
- From:
Chinese Journal of Immunology
2016;32(6):863-866
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the expression of MMP-9 in nasal NK/T cell lymphoma, HIF-1a and its relationship with the clinical and pathologic characteristics. Methods:46 cases ( case group) of paraffin block specimens from patients with pathologically confirmed nasal NK/T cell lymphoma were collected from the Affiliated Hospital of Youjiang Medical College For Nationalities,the same period endoscopy turbinate mucosa were confirmed by pathology in 20 cases of chronic inflammation of mucosa specimens ( control group) , respectively HE staining and immunohistochemistry handle two specimens, observation of the expression differences of two groups of specimens of pathological morphology, MMP-9 and HIF-1a, and to analyze its relationship with the clinical and pathological features of the patients. Results: Case group HIF-1a expression rate 67. 39% (31/46), expression was 6. 52% (3/20) in control group. , the HIF-1a case group were significantly higher than control group (P<0. 05). Case group MMP-9 expression rate 71. 74%(33/46), in the control group expression was 6. 52% (3/20), MMP-9 expression in the case group was significantly higher than control group (P<0. 05). HIF-1a and MMP-9 in positive expression in Ann Arbor staging (Ⅲ-Ⅳ), lymph node metastasis, vascular invasion in patients with nasal NK/T cell lymphoma tissue appeared a high expression ( P< 0. 05 ) . Conclusion: Nasal NK/T cell lymphoma tissue of patients with HIF-1a, MMP-9 presented high expression, and there was a certain relationship between Arbor Ann stage (Ⅲ-Ⅳ) , lymph node metastasis and vascular invasion.
