The effect of Naa10p on the sensitivity of tongue squamous cell carcinoma Tca8113 cells to pingyangmycin
10.3969/j.issn.1001-3733.2016.03.011
- VernacularTitle:Naa10p 表达对舌鳞癌 Tca8113细胞平阳霉素敏感性的影响
- Author:
Jun ZHENG
;
Yang YANG
;
Jiang XU
;
Juan ZHAO
;
Kainan ZHANG
;
Yan ZENG
- Publication Type:Journal Article
- Keywords:
N-acetyltransferase 10(Naa10p);
Oral squamous cell carcinoma;
Pingyangmycin;
Sensitivity
- From:
Journal of Practical Stomatology
2016;32(3):350-353
- CountryChina
- Language:Chinese
-
Abstract:
Objective:To study the effect of N-acetyltransferase 10(Naa10p)expression on the sensitivity of tongue squamous cell carcinoma Tca8113 cells to pingyangmycin(PYM).Methods:The lentiviral vectors of LV-shNaa10p,LV-Naa10p and control LV-NC were transfected into Tca8113 cells,the infection efficiency were identified,then the sensitivity of the infected cells to PYM was determined by MTS assay.Results:The IC50 of Tca8113-LV-shNaa10p group,Tca8113-LV-Naa10p group and Tca8113-LV-NC group were (20.772 ±0.106)μg/ml,(2.157 ±0.123)μg/ml and (6.301 ±0.069)μg/ml respectively(between groups P <0.05).Con-clusion:Knock down of Naa10p may reduce and over expression of Naa10p can increase the sensitivity of Tca8113 cells to PYM.
