The expression and significance of NEK2 mRNA in oral squamous cell carcinoma
- VernacularTitle:NEK2基因在口腔鳞状细胞癌中的表达及意义
- Author:
Hao CHEN
;
Hong MA
;
Xiaofeng DUAN
;
Kunjun SUN
- Publication Type:Journal Article
- Keywords:
NIMA-related kinase 2(Nek2);
Oral squamous cell carcinoma(OSCC);
Real-time PCR
- From:
Journal of Practical Stomatology
2016;32(3):436-438
- CountryChina
- Language:Chinese
-
Abstract:
42 cases of OSCC and 20 of healthy tissues were studied to detect the expression of NIMA-related Kinase 2(NEK2)mRNA by Real-time PCR.Over expression of NEK2 mRNA was observed in OSCC (z =-6.328,P <0.05),the expression was correlated with the differentiation (z =-5.012,P <0.05)and clinical stage (z =-4.950,P <0.05)of the lesion,but not with the lymph node metastasis (z=-0.051,P >0.05),age (z =-0.365,P >0.05)and gender (z =-3.450,P >0.05).NEK2 gene may be involved in the develop-ment of OSCC.
