Analysis ofKIT gene mutation in melanoma patients
10.3969/j.issn.1007-3969.2016.05.008
- VernacularTitle:恶性黑素瘤患者KIT基因突变分析
- Author:
Jiaojie Lü
;
Yunyi KONG
;
Xu CAI
;
Xiaoyan ZHOU
- Publication Type:Journal Article
- Keywords:
KIT;
Gene mutation;
Melanoma
- From:
China Oncology
2016;26(5):399-403
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:KIT mutation plays an important role during the pathogenesis of melanoma. This study was designed to investigate the mutation status ofKIT in different subtypes of melanoma. Methods:A total number of 144 cases of melanoma were analyzed forKIT mutation (exon 9, 11, 13 and 17) by DNA sequencing using paraffin-embedded tissues.Results:The total incidence ofKIT mutation in melanoma was 9.0% (13/144).KIT mutations in acral melanoma, mucosal melanoma, melanoma on skin with chronic sun-induced damage (CSD) and melanoma on skin without chronic sun-induced damage (non-CSD) was 7.7% (4/52), 20% (7/35), 14.3% (1/7) and 2.8% (1/36), respectively. Among 13 cases withKIT mutation, 1 mutation lay in exon 9, 9 lay in exon 11 and 3 in exon 13. L576P in exon 11 was the most common type of mutation.Conclusion:The most prevalent type ofKIT mutation in patients lies in exon 11.KIT mutation could be the potential drug target in melanoma therapy.
