The differences inexpressions of EGFR and VEGF between Han and Uygur triple-negative breast cancer patients
10.3969/j.issn.1007-3969.2016.05.009
- VernacularTitle:EGFR及VEGF在汉族与维吾尔族女性三阴性乳腺癌中的表达差异分析
- Author:
Weihua JIANG
;
Yongtao LI
;
Xiaowen WANG
;
Mingshuai ZHANG
;
Chenguang ZHANG
;
Lina YI
;
Jianghua OU
- Publication Type:Journal Article
- Keywords:
Endothelial growth factor receptor;
Vascular endothelial growth factor;
Han;
Uygur;
Triple-negative breast cancer
- From:
China Oncology
2016;26(5):404-408
- CountryChina
- Language:Chinese
-
Abstract:
Background and purpose:Triple-negative breast cancer (TNBC) is currently the focus of breast cancer research. Researches demonstrated that the molecular biological characteristics of different ethnic groups are not the same. This study mainly probed into the expression of endothelial growth factor receptor (EGFR) and vascular endothelial growth factor (VEGF) in Han and Uygur TNBC patients, and the relationship between the expression and prognosis of patients.Methods:From Jan. 2007 to Jan. 2009, 167 patients were admitted. Among those, 121 were Han and 46 were Uygur patients. The expressions of EGFR, and VEGF were detected by PV-9000 immunohistochemical staining, and compared with lymph node metastasis and clinical staging. The results were analyzed by SPSS 18.0 statistical software.Results:Five-year disease-free survival (DFS) of two groups had no indifferent (P>0.05). EGFR and VEGF positive rate of Han patients was lower than that of Uygur patients (P<0.05). Their expressions were correlated with TNM staging and lymph node metastasis (00.05). Uygur TNBC patients might have a different prognostic factor as compared with Han patients. Further studies need to be carried out.
