A retrospective analysis of liver transplantation in treating endstage autoimmune liver disease
10.3760/cma.j.issn.0254-1785.2015.08.009
- VernacularTitle:肝移植治疗终末期自身免疫性肝病的预后分析
- Author:
Mingqi SHUAI
;
Lei GENG
;
Sheng YAN
;
Zhiwei LI
;
Lin ZHANG
;
Zhiyun CHEN
;
Shusen ZHENG
- Publication Type:Journal Article
- Keywords:
Autoimmune liver disease;
Liver transplantation;
Prognosis
- From:
Chinese Journal of Organ Transplantation
2015;36(8):486-489
- CountryChina
- Language:Chinese
-
Abstract:
Objective Investigate the prognosis of patients undergoing liver transplantation (LT) for end-stage autoirnmune liver disease (ALD).Method The clinical data of 45 patients with endstage ALD undergoing LT from April 2001 to March 2015 in the first affiliated hospital of Zhejiang University were analyzed retrospectively.The postoperative cumulative survival rate of the recipients was calculated,and the causes of death were analyzed.The postoperative rejections,new onset viral hepatitis and ALD recurrence were also analyzed.Result In 45 ALD recipients,33 cases survived and the postoperative 5-year cumulative survival rate was 78.8％.Causes for 12 dead cases were mnultiple organ failure,liver graft failure,respiratory complications,hemorrhage and hepatic artery embolization.In 45 ALD recipients,6 cases suffered rejection after operation with the incidence bing 13.3％.One case suffered new onset hepatitis B infection 8 years after opcration.One recipient suffered primary disease (primary biliary cirrhosis) recurrence 2 years after operation,and 1 recipient with primary disease (primary sclerosing cholangitis) developed into overlap syndrome.They all survived for a long term after active treatments.Conclusion Most LT recipients with endstage ALD can obtain a long term survival.Attentions should be paid to the immunosuppressive regimens in early period after LT,prevention of infection,rejection and postoperative new onset viral hepatitis,and timely diagnosis of primary disease recurrence.
