MMP-9, HIF-1 and SIRT1 in acute lung injury: a review
10.3760/cma.j.issn.1671-0282.2016.03.029
- VernacularTitle:MMP-9、HIF-1和SIRT1在急性肺损伤中的研究进展
- Author:
Yao TONG
;
Quan LI
- Publication Type:Journal Article
- Keywords:
Matrix metalloproteinase;
Hypoxia-inducible factor-1;
Silent information regulator2-related enzymes 1;
Acute lung injury
- From:Chinese Journal of Emergency Medicine
2016;25(3):384-388
- CountryChina
- Language:Chinese
-
Abstract:
Matrix metallopeptidase 9 (MMP-9) is a group of enzymes that belong to the zine-metalloproteinases family involved in the pathophysiological process of various diseases,such as inflammation,angiogenesis and tumor invasion.Hypoxia-inducible factor-1 (HIF-1) is a nucleoprotein with transcription activity,which consists of two different subunits,α and β.It plays an important role in the process of the formation of new blood vessels following ischemic necrosis and the process of hypoxia induced cell apoptosis.Silent information regulator2-related enzymes 1 (SIRT1) is a NAD-dependent deacetylase sirtuin,which belongs to a member of the sirtuin family of proteins,also involved in many pathophysiologic processes,such as aging,cell death and tumorigenesis.This study aims to review the role of MMP-9,HIF-1 and SIRT1 in acute lung injury.
