Research progress on androgen receptor in triple-negative breast carcinoma
10.3969/j.issn.1007-3969.2016.05.020
- VernacularTitle:三阴性乳腺癌雄激素受体研究进展
- Author:
Xiaoli LIU
;
Da JIANG
;
Yanzhi CUI
- Publication Type:Journal Article
- Keywords:
Triple-negative breast cancer;
Androgen receptor;
Expression
- From:
China Oncology
2016;26(5):466-470
- CountryChina
- Language:Chinese
-
Abstract:
Triple-negative breast cancers (TNBC) comprise a heterogeneous group of tumors characterized by poor survival and lack of targeted therapeutics. In recent years, androgen receptor (AR) has been demonstrated to play an important role in the genesis and development of TNBC. There has been increased interest in the role of AR in TNBC and AR-targeting has been introduced as a novel therapeutic option for TNBC. This review offers an overview of the relationship between AR expression and TNBC, and provides insights into the novel drugs in the development for targeting this signaling pathway.
